INTU

Description		inturned planar cell polarity protein
Image
GO Annotations	Cellular Component	Cytoplasm Centriole Cytosol Cytoskeleton Cilium Cell Surface Motile Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding Phosphatidylinositol Binding
	Biological Process	Establishment Of Planar Polarity Smoothened Signaling Pathway Nervous System Development Regulation Of Smoothened Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Vesicle-mediated Transport Spinal Cord Dorsal/ventral Patterning Neural Tube Development Cell Projection Organization Keratinocyte Differentiation Regulation Of Ossification Hair Follicle Morphogenesis Protein Localization To Organelle Intraciliary Transport Embryonic Digit Morphogenesis Tongue Morphogenesis Motile Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Division Negative Regulation Of Cell Division Roof Of Mouth Development Limb Development Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly
Pathways		Hedgehog 'off' state
Drugs
Diseases
GWAS		Facial morphology ( 31763980) Lung function in heavy smokers (high FEV1 vs average FEV1) ( 26423011) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)
Novel Interacting Genes		1 novel interacting genes: CFTR
Interacting Genes		1 interacting genes: CFTR
Entrez ID		27152
HPRD ID		15113
Ensembl ID		ENSG00000164066
Uniprot IDs		Q9ULD6
PDB IDs		7Q3D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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