TJP3

Description		tight junction protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)
Novel Interacting Genes		5 novel interacting genes: CLDN1 FASLG GJC1 PATJ TJP1
Interacting Genes		5 interacting genes: CLDN1 FASLG GJC1 PATJ TJP1
Entrez ID		27134
HPRD ID		18194
Ensembl ID		ENSG00000105289
Uniprot IDs		O95049
PDB IDs		3KFV
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Assembly Cell-cell Junction Organization Tight Junction Cell Junction Assembly Anchoring Junction Cell Junction Organization Bicellular Tight Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Bicellular Tight Junction Assembly Cell Junction Gap Junction Apical Junction Complex Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Cellular Component Maintenance Cellular Response To Type II Interferon Apical Part Of Cell Xenobiotic Transport Across Blood-nerve Barrier Response To Type II Interferon Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Epithelial Cell Development Cellular Response To Butyrate SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Retinal Cell Programmed Cell Death Response To Butyrate Cellular Response To Lead Ion Response To Interleukin-18 Establishment Of Blood-nerve Barrier Cytoplasmic Vesicle Lumen Anatomical Structure Homeostasis Tissue Homeostasis AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Cell Development Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipid Translocation Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Inflammatory Cell Apoptotic Process Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Cellular Component Assembly Basolateral Plasma Membrane
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