DKK2

Description		dickkopf Wnt signaling pathway inhibitor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heel bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 27182965 28196072) Resting-state electroencephalogram vigilance ( 29703947) Telomere length ( 24478790)
Novel Interacting Genes		2 novel interacting genes: KRTAP10-6 LRP6
Interacting Genes		2 interacting genes: KRTAP10-6 LRP6
Entrez ID		27123
HPRD ID		05658
Ensembl ID		ENSG00000155011
Uniprot IDs		Q9UBU2
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signalosome Wnt-Frizzled-LRP5/6 Complex Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Toxin Transmembrane Transporter Activity Kinase Inhibitor Activity Low-density Lipoprotein Particle Receptor Activity Neural Crest Formation Neural Crest Cell Differentiation Cellular Response To Cholesterol Negative Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Sterol Response To Cholesterol Protein Serine/threonine Kinase Inhibitor Activity Wnt-protein Binding Midbrain Development Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Muscle Cell Apoptotic Process Coreceptor Activity
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