PDE7B

Description		phosphodiesterase 7B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Synapse
	Molecular Function	Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction Chemical Synaptic Transmission Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events
Drugs		Caffeine Trapidil
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Aspartate aminotransferase levels ( 31219225) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) BRCA1/2-negative high-risk breast cancer ( 30323354) Cirrhosis (alcohol related) ( 32853455) Delirium ( 29631748) Diverticulitis ( 28585551) Glaucoma ( 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549 28869591) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29617998 29785010 30054594 31959993 24002674) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Phosphorus levels ( 20558539)
Novel Interacting Genes		1 novel interacting genes: SRPK2
Interacting Genes		1 interacting genes: SRPK2
Entrez ID		27115
HPRD ID		06870
Ensembl ID		ENSG00000171408
Uniprot IDs		Q9NP56
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Speck Organization R-loop Processing Peptidyl-serine Phosphorylation 14-3-3 Protein Binding Nuclear Body Organization Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Neuron Apoptotic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Positive Regulation Of Viral Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleus Organization Regulation Of Viral Life Cycle Regulation Of MRNA Splicing, Via Spliceosome
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