AMPD2

Description		adenosine monophosphate deaminase 2
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	IMP Biosynthetic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process IMP Salvage Cholesterol Homeostasis AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Podocyte Development Energy Homeostasis
Pathways		Purine salvage
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Major depressive disorder ( 20125088) Seasonality and depression ( 30217971)
Novel Interacting Genes		6 novel interacting genes: AMPD1 CCNDBP1 NEDD4 NTAQ1 POT1 TERF1
Interacting Genes		6 interacting genes: AMPD1 CCNDBP1 NEDD4 NTAQ1 POT1 TERF1
Entrez ID		271
HPRD ID		11808
Ensembl ID		ENSG00000116337
Uniprot IDs		Q01433
PDB IDs		4NO3 4NO5 8HU6 8HUB
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Channel Inhibitor Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Positive Regulation Of Telomeric Loop Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Telomere Organization Negative Regulation Of DNA Metabolic Process AMP Deaminase Activity Phosphothreonine Residue Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region IMP Salvage GMP Salvage
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