GIP

Description		gastric inhibitory polypeptide
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen
	Molecular Function	Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding Receptor Ligand Activity
	Biological Process	Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Memory Adult Locomotory Behavior Response To Glucose Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Exploration Behavior Gastric Inhibitory Peptide Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Response To Starvation Regulation Of Insulin Secretion
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Tirzepatide
Diseases
GWAS		Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Blood glucose levels ( 31928498) Coronary artery disease ( 29212778) Coronary heart disease ( 21378990) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Liver enzyme levels (alkaline phosphatase) ( 33972514) Systolic blood pressure ( 30578418 31928498) Type 2 diabetes ( 28566273 29358691) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		6 novel interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA SGTB
Interacting Genes		6 interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA SGTB
Entrez ID		2695
HPRD ID		15925
Ensembl ID		ENSG00000159224
Uniprot IDs		P09681
PDB IDs		1T5Q 2B4N 2L70 2L71 2OBU 2QKH 7DTY 7RA3
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Glucagon Family Peptide Binding Gastric Inhibitory Peptide Receptor Activity Protein Targeting To Membrane Pigment Cell Development Gastric Inhibitory Peptide Signaling Pathway Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Establishment Of Protein Localization To Membrane Protein Targeting BAT3 Complex Binding Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Interstitial Matrix
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