CBLIF

Description		cobalamin binding intrinsic factor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen
	Molecular Function	Protein Binding Cobalamin Binding Molecular Carrier Activity Cargo Receptor Ligand Activity
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport
Pathways		Defective CBLIF causes IFD Defective AMN causes MGA1 Defective CUBN causes MGA1 Uptake of dietary cobalamins into enterocytes
Drugs
Diseases
GWAS
Novel Interacting Genes		8 novel interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237
Interacting Genes		8 interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237
Entrez ID		2694
HPRD ID		02024
Ensembl ID		ENSG00000134812
Uniprot IDs		P27352
PDB IDs		2PMV 3KQ4
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Activity Plasma Membrane Amino Acid Transmembrane Transporter Activity Symbiont Entry Into Host Cell Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Amino Acid Transport Lysine Transport L-ornithine Transmembrane Transport Amino Acid Transmembrane Transport Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-histidine Import Across Plasma Membrane Extrinsic Component Of External Side Of Plasma Membrane Sodium:sulfate Symporter Activity Import Into Cell Ubiquitin-dependent Endocytosis Biological Process Involved In Interaction With Host Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction L-lysine Transmembrane Transport Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-arginine Import Across Plasma Membrane Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Leukocyte Chemotaxis Involved In Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Cobalamin Transport Cobalamin Metabolic Process Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Aromatic Amino Acid Transport Cobalamin Binding L-arginine Transmembrane Transport
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