NPAS4

Description		neuronal PAS domain protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Postsynapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Learning Short-term Memory Long-term Memory Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Cellular Response To Stress Social Behavior Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Cellular Response To Corticosterone Stimulus Inhibitory Synapse Assembly
Pathways		Regulation of NPAS4 mRNA translation NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) General risk tolerance (MTAG) ( 30643258) Left-handedness ( 32989287) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		4 novel interacting genes: ARNT ARNT2 BMAL1 MAGED1
Interacting Genes		4 interacting genes: ARNT ARNT2 BMAL1 MAGED1
Entrez ID		266743
HPRD ID		12260
Ensembl ID		ENSG00000174576
Uniprot IDs		Q8IUM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Protein Dimerization Activity Transcription Regulator Complex Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Oxidative Stress-induced Premature Senescence DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CLOCK-BMAL Transcription Complex Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Acetylation Stress-induced Premature Senescence Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Hypoxia Positive Regulation Of Developmental Process Response To Decreased Oxygen Levels Intestinal Epithelial Structure Maintenance Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Response To Oxygen Levels Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Sumoylation Chromatoid Body Regulation Of Cell Population Proliferation Response To Redox State Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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