GCKR

Description		glucokinase regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Kinase Inhibitor Activity Fructose-6-phosphate Binding Carbohydrate Derivative Binding Glucose Sensor Activity
	Biological Process	Intracellular Glucose Homeostasis Protein Import Into Nucleus Response To Glucose Response To Fructose Negative Regulation Of Glucokinase Activity Protein Localization To Nucleus Urate Metabolic Process Triglyceride Homeostasis Carbohydrate Derivative Metabolic Process
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Bitter alcoholic beverage consumption ( 31046077) Bitter beverage consumption ( 31046077) Blood glucose levels ( 29615537) Blood protein levels in cardiovascular risk ( 28369058) Blood sugar levels ( 29403010) Body mass index and LDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Breast size ( 22747683) C-reactive protein ( 18439548) C-reactive protein levels ( 21300955 29403010 29878111 30388399 33339817) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Calcium levels ( 20705733 24068962) Cardiovascular disease risk factors ( 21943158) Chloride levels ( 29403010) Cholesterol ( 31902109) Cholesterol, total ( 20686565 24097068 25961943 26582766) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 20383146 29124443) circulating leptin levels ( 26833098 32917775) circulating leptin levels adjusted for BMI ( 26833098 32917775) Circulating leptin levels or fasting insulin levels ( 32341051) Circulating leptin levels or HOMA-IR ( 32341051) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 25288136 31837886) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Crohn's disease ( 21102463 28067908) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Fasting blood glucose ( 20081858 22581228 25631608 33842983) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood insulin ( 20081858 22581228 25631608) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Fasting plasma glucose ( 22508271 25187374 28270201) Fasting triglyceride levels ( 32603185) Gallstone disease ( 27094239 30504769) Gamma glutamyl transferase levels ( 29403010 33339817) Gestational insulin sensitivity ( 32556615) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Gondoic acid (20:1n-9) levels ( 28298293) Gout ( 25646370 27899376 31578528 32238385 33832965) Gout (combined type) ( 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 31562340) Hematocrit ( 27863252 32888494) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Homeostasis model assessment of insulin resistance ( 20081858) Hypertriglyceridemia ( 20657596 23505323 27599772 31910446) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Iron status biomarkers (ferritin levels) ( 33536631) Kidney stones ( 31729369) L-selectin levels ( 25576479) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 18179892 30275531) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24023260 24386095) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver volume ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910 21886157) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 21909109 22286219 22916037) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 29385134 34841290) Nonalcoholic steatohepatitis ( 32298765) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Percent glycated albumin ( 29844224) Phospholipid levels (plasma) ( 22359512) Plasma lactate levels ( 26433129) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet count ( 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Postprandial triglyceride levels ( 32603185) Problematic alcohol use ( 32451486) Protein C levels ( 28082259) Prothrombin time ( 29403010) Red blood cell count ( 27863252) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Relative protein intake ( 32393786) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376 32238385) Resting heart rate ( 27798624 29769521) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum albumin levels ( 23022100 29403010) Serum alkaline phosphatase levels ( 31666285 33547301) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels ( 23093944 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum total protein levels ( 23022100 29403010) Serum uric acid levels ( 29403010 30993211) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899 29403010 29615537 30275531 31087446 33339817) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29403010 29615537 30718733 30911093 31087446 31647587 32154731 32759990 32902719 33339817 34074324) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 17463246 18193043 18193044 19060906 19060911 20139978 20686565 20864672 21909109 23726366 24097068 25961943 26160806 26582766 26780889 29404214 30275531) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 26818947 28566273 28869590 29632382 30054458 30297969 30718926 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 20139978 20884846 23263486 31578528 31985003) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary sodium excretion ( 31409800) Urinary sodium to creatinine ratio ( 30910378) Urolithiasis ( 30975718) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146) White blood cell count ( 24777453 27863252 29403010 32888494)
Novel Interacting Genes		7 novel interacting genes: ATP5MG CDKN1A CFTR CSDE1 EP300 GCK TRAF2
Interacting Genes		7 interacting genes: ATP5MG CDKN1A CFTR CSDE1 EP300 GCK TRAF2
Entrez ID		2646
HPRD ID		02909
Ensembl ID		ENSG00000084734
Uniprot IDs		A0A0C4DFN2 Q14397
PDB IDs		4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Negative Regulation Of Gluconeogenesis ATP Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intracellular Signaling Cassette Protein-containing Complex Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport ADP Catabolic Process Purine Ribonucleotide Metabolic Process ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Regulation Of Glycolytic Process Ribose Phosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Regulation Of Gluconeogenesis Glycolytic Process Ribonucleotide Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Nucleobase-containing Compound Catabolic Process Regulation Of ATP Metabolic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Purine Nucleotide Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Negative Regulation Of Catabolic Process Histone Crotonyltransferase Activity TORC1 Signaling TORC2 Complex Disassembly MRNA Stabilization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleotide Metabolic Process Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of MRNA Catabolic Process Purine Ribonucleotide Catabolic Process RNA Stabilization
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