GCK

Description		glucokinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Glucose Sensor Activity
	Biological Process	Intracellular Glucose Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Glycolytic Process Regulation Of Glycolytic Process Purine Nucleotide Metabolic Process NADP+ Metabolic Process Response To Glucose Hexose Metabolic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Regulation Of Potassium Ion Transport Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Calcium Ion Import
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases		Permanent neonatal diabetes mellitus (PNDM) Maturity onset diabetes of the young (MODY)
GWAS		Birth weight ( 27680694 31043758) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 20081858 25631608 33842983 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 19060907 25187374) Fructosamine levels ( 34753797) Glycated hemoglobin levels ( 31213470 34059833 19096518 28898252 24647736 20858683 24244560) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 31928498 32154731 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 30718926 22885922 32499647 30297969)
Novel Interacting Genes		8 novel interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 PRKN RALA SPDYE4
Interacting Genes		8 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 PRKN RALA SPDYE4
Entrez ID		2645
HPRD ID		00680
Ensembl ID		ENSG00000106633
Uniprot IDs		A0A5F9ZGW4 H7BXV0 P35557 Q53Y25
PDB IDs		1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I 7T78 7T79
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glucokinase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Fructose Metabolic Process Glucose Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Response To L-glutamate Positive Regulation Of Mitochondrial Fission Carbohydrate Phosphorylation Hexose Metabolic Process Monosaccharide Metabolic Process Regulation Of Catalytic Activity Regulation Of Secretion By Cell Regulation Of Mitochondrial Fission Regulation Of Peptide Hormone Secretion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Secretion Positive Regulation Of ATP Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Glycolytic Process ADP Catabolic Process Gluconeogenesis Purine Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion By Cell ADP Metabolic Process Hexose Biosynthetic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Pyruvate Metabolic Process Negative Regulation Of Spontaneous Neurotransmitter Secretion PCNA Complex Replisome Negative Regulation Of Protein Secretion Regulation Of ATP Metabolic Process Negative Regulation Of Kinase Activity Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process
Tagcloud ?