FBXL4

Description		F-box and leucine rich repeat protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Cytosol Membrane Nuclear Speck SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Autophagy Of Mitochondrion Mitophagy Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitophagy
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Depression ( 29700475) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889)
Novel Interacting Genes		6 novel interacting genes: BNIP3 BNIP3L GP1BA MAP3K7 RXRG SKP1
Interacting Genes		6 interacting genes: BNIP3 BNIP3L GP1BA MAP3K7 RXRG SKP1
Entrez ID		26235
HPRD ID		05738
Ensembl ID		ENSG00000112234
Uniprot IDs		Q9UKA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Decreased Oxygen Levels Mitochondrial Protein Catabolic Process Positive Regulation Of Macroautophagy Cellular Response To Hypoxia Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Cellular Response To Oxygen Levels Positive Regulation Of Autophagy Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Macroautophagy Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Process Response To Hypoxia Cell Death Response To Decreased Oxygen Levels Programmed Cell Death Regulation Of Autophagy Of Mitochondrion Response To Oxygen Levels Regulation Of Mitochondrial Membrane Permeability Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Mitochondrial Membrane Organization Protein Metabolic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia F-box Domain Binding I-kappaB Phosphorylation Linear Polyubiquitin Binding Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Cul7-RING Ubiquitin Ligase Complex Autophagic Cell Death Glycoprotein Ib-IX-V Complex Thrombin-activated Receptor Activity Catabolic Process Mitochondrial Outer Membrane
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