TRPC4AP

Description		transient receptor potential cation channel subfamily C member 4 associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Calcium Channel Activity Protein Binding Phosphatase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		TRP channels
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		17 novel interacting genes: CHMP4C CHUK CPNE1 EDEM2 IKBKB IKBKG MED26 MTDH PCDH11X PGLYRP4 RIPK1 TAB1 TNFRSF1A TRADD TRAF2 UQCC1 VMP1
Interacting Genes		17 interacting genes: CHMP4C CHUK CPNE1 EDEM2 IKBKB IKBKG MED26 MTDH PCDH11X PGLYRP4 RIPK1 TAB1 TNFRSF1A TRADD TRAF2 UQCC1 VMP1
Entrez ID		26133
HPRD ID		09238
Ensembl ID		ENSG00000100991
Uniprot IDs		B4DW48 Q8TEL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Transferrin Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor IkappaB Kinase Activity Death Domain Binding Positive Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Tumor Necrosis Factor Binding Death-inducing Signaling Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Receptor Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response Inflammatory Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Endothelial Barrier Regulation Of Signal Transduction Defense Response Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Immune System Process Protein Heterodimerization Activity Innate Immune Response
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