LRIG1

Description		leucine rich repeats and immunoglobulin like domains 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Sensory Perception Of Sound Hair Cycle Process Otolith Morphogenesis Innervation
Pathways		Signaling by EGFR Negative regulation of MET activity Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Antibody status in Tripanosoma cruzi seropositivity ( 24324551) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Blood urea nitrogen levels ( 29403010) Carotid intima media thickness ( 21909108) Chronic kidney disease ( 29124443) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29124443) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 29124443) Hyperuricemia ( 29124443) Intraocular pressure ( 30054594) Iron status biomarkers (iron levels) ( 33536631) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Non-glioblastoma glioma ( 28346443) Orofacial clefts ( 33137956) Pulse pressure ( 27841878) QRS duration ( 27659466 27577874 21076409) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Retinal detachment or retinal break ( 31816047) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27841878) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Novel Interacting Genes		5 novel interacting genes: CBL GLRX3 MICOS10-NBL1 NBL1 ZBTB16
Interacting Genes		5 interacting genes: CBL GLRX3 MICOS10-NBL1 NBL1 ZBTB16
Entrez ID		26018
HPRD ID		10057
Ensembl ID		ENSG00000144749
Uniprot IDs		Q96JA1
PDB IDs		4U7L 4U7M
Enriched GO Terms of Interacting Partners?		Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Regionalization Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Pattern Specification Process Maintenance Of Protein Location Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Maintenance Of Location Positive Regulation Of Neuron Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Identical Protein Binding Receptor Ligand Activity Type 2 Angiotensin Receptor Binding Regulation Of Mononuclear Cell Migration Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Rap Protein Signal Transduction Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Chemotaxis Ubiquitin-dependent Endocytosis Regulation Of Leukocyte Migration Regulation Of NK T Cell Differentiation System Development Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Ossification Involved In Bone Maturation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Mesonephros Development
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