MMACHC

Description		metabolism of cobalamin associated C
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Oxidoreductase Activity Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Demethylase Activity Cyanocobalamin Reductase (cyanide-eliminating) (NADP+) Activity Protein Homodimerization Activity Glutathione Binding FAD Binding
	Biological Process	Glutathione Metabolic Process Cobalamin Metabolic Process Demethylation
Pathways		Defective MMADHC causes MMAHCD Defective MMACHC causes MAHCC Cobalamin (Cbl) metabolism
Drugs		Cyanocobalamin Hydroxocobalamin
Diseases		Methylmalonic aciduria (MMA)
GWAS		Homocysteine levels ( 23824729)
Novel Interacting Genes		2 novel interacting genes: KDM4A MMADHC
Interacting Genes		2 interacting genes: KDM4A MMADHC
Entrez ID		25974
HPRD ID		18585
Ensembl ID		ENSG00000132763
Uniprot IDs		A0A0C4DGU2 Q9Y4U1
PDB IDs		3SBY 3SBZ 3SC0 3SOM 5UOS 7WUZ
Enriched GO Terms of Interacting Partners?		Histone H3K36me2/H3K36me3 Demethylase Activity Cardiac Muscle Hypertrophy In Response To Stress Histone H3K9 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity Molecular Carrier Activity Cobalamin Metabolic Process Cardiac Muscle Hypertrophy Histone Demethylase Activity Muscle Hypertrophy Pericentric Heterochromatin Tetrapyrrole Metabolic Process Dioxygenase Activity Negative Regulation Of Autophagy
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