CLIC4

Description		chloride intracellular channel 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Cell-cell Junction Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Nuclear Matrix Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Angiogenesis Endothelial Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Vacuolar Acidification Fertilization Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Monoatomic Ion Transmembrane Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Branching Morphogenesis Of An Epithelial Tube Regulation Of Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Cellular Response To Calcium Ion Chloride Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Height ( 20881960) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)
Novel Interacting Genes		8 novel interacting genes: ACTB CLIC6 DNM1 ERCC6 HSP90AB1 REL TPRN YWHAZ
Interacting Genes		8 interacting genes: ACTB CLIC6 DNM1 ERCC6 HSP90AB1 REL TPRN YWHAZ
Entrez ID		25932
HPRD ID		05943
Ensembl ID		ENSG00000169504
Uniprot IDs		Q6FIC5 Q9Y696
PDB IDs		2AHE 2D2Z 3OQS
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Protein Kinase Binding Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein HSP90-CDC37 Chaperone Complex Melanosome Synaptic Target Recognition Protein Phosphatase Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Extracellular Exosome Blood Microparticle Transporter Regulator Activity D2 Dopamine Receptor Binding Stereocilium Maintenance Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Chromaffin Granule NF-kappaB Complex Stereocilium Base Regulation Of Double-strand Break Repair Protein Localization To Adherens Junction Dense Body Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Golgi Reassembly Nucleoplasm Morphogenesis Of A Polarized Epithelium Response To Superoxide Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Vesicle DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical ATP-dependent Protein Binding B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
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