ZNF521

Description		zinc finger protein 521
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Neuron Fate Commitment
Pathways		RUNX2 regulates osteoblast differentiation Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Height ( 31562340) High density lipoprotein cholesterol levels ( 30498476) Mitochondrial DNA levels ( 25240745) Myeloproliferative neoplasms ( 33057200) Nickel levels ( 26025379) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Systemic juvenile idiopathic arthritis ( 27927641) Takayasu arteritis ( 25604533) Toenail selenium levels ( 25343990) Urgency urinary incontinence ( 25524241) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		9 novel interacting genes: BRAP CFAP298 EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4
Interacting Genes		9 interacting genes: BRAP CFAP298 EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4
Entrez ID		25925
HPRD ID		18350
Ensembl ID		ENSG00000198795
Uniprot IDs		J3KTI4 Q8IYZ2 Q96K83
PDB IDs
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding Cardiac Conduction System Development SMAD Protein Signal Transduction Cell Fate Commitment DNA-binding Transcription Factor Activity Transcription Regulator Complex MAPK Cascade Transcription Coactivator Binding Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Embryonic Pattern Specification Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Mast Cell Secretory Granule Organization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-templated Transcription Sequence-specific DNA Binding Nucleoplasm Basophil Differentiation Male Gonad Development Regulation Of Definitive Erythrocyte Differentiation Eosinophil Fate Commitment Regulation Of Primitive Erythrocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesodermal Cell Fate Commitment Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Primitive Erythrocyte Differentiation Striated Muscle Tissue Development
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