TRIM58

Description		tripartite motif containing 58
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Zinc Ion Binding Transferase Activity Dynein Heavy Chain Binding Dynein Intermediate Chain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Protein Autoubiquitination Positive Regulation Of Erythrocyte Enucleation Regulation Of Nuclear Migration Along Microtubule
Pathways
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010) Mean corpuscular volume ( 27863252 32888494 28017375 28453575 20139978 29403010) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 29403010 27863252 22139419) Platelet distribution width ( 32888494 27863252) Red blood cell count ( 32888494 27863252) Red blood cell fatty acid levels ( 25500335) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum metabolite levels ( 33031748) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 27863252 32888494)
Novel Interacting Genes		3 novel interacting genes: DYNC1I1 MECOM UBE2D3
Interacting Genes		3 interacting genes: DYNC1I1 MECOM UBE2D3
Entrez ID		25893
HPRD ID		09825
Ensembl ID		ENSG00000162722
Uniprot IDs		Q8NG06
PDB IDs		8PD4 8PD6
Enriched GO Terms of Interacting Partners?		Dynein Light Chain Binding Histone H3K9me2 Methyltransferase Activity Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone H3K9 Monomethyltransferase Activity Histone H3K9 Methyltransferase Activity
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