GALE

Description		UDP-galactose-4-epimerase
Image
GO Annotations	Cellular Component	Cytosol
	Molecular Function	UDP-N-acetylglucosamine 4-epimerase Activity UDP-glucose 4-epimerase Activity Isomerase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Galactose Metabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway
Pathways		Defective GALE causes EDG Galactose catabolism
Drugs		Uridine diphosphate glucose Uridine-Diphosphate-N-Acetylgalactosamine UDP-alpha-D-glucuronic acid Tetramethylammonium Uridine-Diphosphate-N-Acetylglucosamine Galactose-uridine-5'-diphosphate
Diseases		Galactosemia
GWAS
Novel Interacting Genes		3 novel interacting genes: APP MUC1 PLA2G5
Interacting Genes		3 interacting genes: APP MUC1 PLA2G5
Entrez ID		2582
HPRD ID		06092
Ensembl ID		ENSG00000117308
Uniprot IDs		A0A384NL38 Q14376
PDB IDs		1EK5 1EK6 1HZJ 1I3K 1I3L 1I3M 1I3N
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Golgi Lumen Recycling Endosome Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Antifungal Innate Immune Response Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Phagosome Maturation Regulation Of Phagosome Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Phagolysosome Positive Regulation Of Phospholipase Activity Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Negative Regulation Of Cell Adhesion Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Positive Regulation Of Lipase Activity
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