TTLL1

Description		TTL family tubulin polyglutamylase complex subunit L1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Motile Cilium Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding ATP Binding Tubulin Binding Ligase Activity Metal Ion Binding Tubulin-glutamic Acid Ligase Activity Protein-glutamic Acid Ligase Activity, Elongating
	Biological Process	Microtubule Cytoskeleton Organization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Epithelial Cilium Movement Involved In Extracellular Fluid Movement Sperm Axoneme Assembly Protein Polyglutamylation Cerebellar Purkinje Cell Differentiation Flagellated Sperm Motility Axoneme Assembly Microtubule Polymerization Cilium Disassembly Mucociliary Clearance Regulation Of Blastocyst Development
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Uric acid elevation in response to thiazide-like diuretic in hypertension ( 31748705)
Novel Interacting Genes		1 novel interacting genes: LRRK2
Interacting Genes		1 interacting genes: LRRK2
Entrez ID		25809
HPRD ID		10604
Ensembl ID		ENSG00000100271
Uniprot IDs		O95922
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Protein Autoubiquitination Response To Curcumin Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Multivesicular Body, Internal Vesicle Regulation Of Kidney Size Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Positive Regulation Of Microglial Cell Activation Protein Localization To Endoplasmic Reticulum Exit Site Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Response To Dopamine JUN Kinase Kinase Kinase Activity Regulation Of Neuron Maturation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Manganese Ion Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Dopamine Receptor Signaling Pathway Cellular Response To Ether Negative Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Autophagosome Assembly Co-receptor Binding Autolysosome Wnt Signalosome Intracellular Organelle Lumen Regulation Of SNARE Complex Assembly Locomotory Exploration Behavior Striatum Development Negative Regulation Of GTPase Activity Response To Manganese Ion Golgi-associated Vesicle Protein Localization To Endoplasmic Reticulum
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