BAMBI

Description		BMP and activin membrane bound inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Fasting glucose change (long-term) ( 31263163) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Percentage gas trapping ( 26030696) Preeclampsia ( 23551011)
Novel Interacting Genes		9 novel interacting genes: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B NKG7 SELENOF SOX30 TGFBR1
Interacting Genes		9 interacting genes: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B NKG7 SELENOF SOX30 TGFBR1
Entrez ID		25805
HPRD ID		05117
Ensembl ID		ENSG00000095739
Uniprot IDs		Q13145
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Activin Receptor Activity, Type I BMP Receptor Activity Activin Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Activin Receptor Complex Positive Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Protein Kinase Activity BMP Signaling Pathway In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Signaling Pathway Kinase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Ossification Pattern Specification Process Ventricular Septum Morphogenesis Positive Regulation Of Bone Mineralization Positive Regulation Of Cell Differentiation Growth Factor Binding BMP Receptor Complex Positive Regulation Of Biomineral Tissue Development Receptor Complex Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Artery Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Osteoblast Differentiation Mitral Valve Morphogenesis Regulation Of Cartilage Development Dorsal Aorta Morphogenesis Transforming Growth Factor Beta Receptor Activity HFE-transferrin Receptor Complex Ventricular Compact Myocardium Morphogenesis
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