GAK

Description		cyclin G associated kinase
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Anchoring Junction Presynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Clathrin Binding Cyclin Binding Protein Folding Chaperone Protein Serine Kinase Activity
	Biological Process	Protein Folding Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Intracellular Transport Clathrin Coat Assembly Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Regulation Of Clathrin Coat Assembly
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs		Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 32310270 27182965 25064009 22438815 21738487 21292315) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		15 novel interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1 WFS1
Interacting Genes		15 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1 WFS1
Entrez ID		2580
HPRD ID		03631
Ensembl ID		ENSG00000178950
Uniprot IDs		B4DS37 O14976
PDB IDs		4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?		Intracellular Transport Intracellular Protein Transport Clathrin Adaptor Complex Regulation Of Protein Localization Clathrin Adaptor Activity Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Low-density Lipoprotein Particle Receptor Binding Regulation Of Protein Import Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Vesicle Clathrin Coat Disassembly Regulation Of Protein Localization To Cell Periphery Vesicle Uncoating Regulation Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Clathrin-coated Pit P53 Binding Clathrin-coated Vesicle Establishment Of Protein Localization AP-1 Adaptor Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Endolysosome Membrane Transcytosis Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Clathrin-coated Endocytic Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Disordered Domain Specific Binding Regulation Of JNK Cascade Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process Positive Regulation Of Receptor Internalization Lysosomal Membrane Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein Localization To Plasma Membrane Enzyme Binding Regulation Of Protein Localization To Nucleus Clathrin-dependent Endocytosis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly
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