GABRD

Description		gamma-aminobutyric acid type A receptor subunit delta
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Chloride Channel Complex Neuronal Cell Body Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport
Pathways
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
GWAS		Body mass index ( 26426971)
Novel Interacting Genes		6 novel interacting genes: CCR8 ETS2 MDFI NOTCH2NLA UBQLN1 UBQLN4
Interacting Genes		6 interacting genes: CCR8 ETS2 MDFI NOTCH2NLA UBQLN1 UBQLN4
Entrez ID		2563
HPRD ID		08842
Ensembl ID		ENSG00000187730
Uniprot IDs		A8K496 O14764
PDB IDs		7QN5 7QN6 7QN7 7QN8 7QN9 7QNC 7QND
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Ectodermal Cell Fate Commitment Nuclear Proteasome Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation
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