GABRA5

Description		gamma-aminobutyric acid type A receptor subunit alpha5
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Membrane Dendrite Dendrite Membrane Neuronal Cell Body Membrane Chloride Channel Complex Presynaptic Membrane Receptor Complex Cell Body Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity GABA Receptor Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Behavioral Fear Response Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Associative Learning Monoatomic Ion Transmembrane Transport Neuron Development Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cochlea Development Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		GABA receptor activation GABA receptor activation
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Zopiclone Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		Body mass index ( 28892062) Crohn's disease ( 32581322) Metabolite levels ( 23823483) Thyroglobulin plasma levels ( 30929638)
Novel Interacting Genes		1 novel interacting genes: DUSP6
Interacting Genes		1 interacting genes: DUSP6
Entrez ID		2558
HPRD ID		08840
Ensembl ID		ENSG00000186297
Uniprot IDs		P31644
PDB IDs		5O8F 5OJM 6A96 8BEJ 8BGI 8BHA 8BHB 8BHG 8BHI 8BHK 8BHM 8BHO 8BHQ 8BHR 8BHS
Enriched GO Terms of Interacting Partners?		Response To Nitrosative Stress Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of Heart Growth Regulation Of Organ Growth Negative Regulation Of ERK1 And ERK2 Cascade ERK1 And ERK2 Cascade Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Phosphoprotein Phosphatase Activity Dephosphorylation Negative Regulation Of MAPK Cascade
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