FZD2

Description		frizzled class receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Perception Of Smell Wnt Signaling Pathway Neuron Differentiation Non-canonical Wnt Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Hard Palate Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Ventricular Septum Morphogenesis Cochlea Morphogenesis
Pathways		TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Pulse pressure ( 30224653)
Novel Interacting Genes		2 novel interacting genes: DLG4 ROR2
Interacting Genes		2 interacting genes: DLG4 ROR2
Entrez ID		2535
HPRD ID		02813
Ensembl ID		ENSG00000180340
Uniprot IDs		Q14332 Q86UZ8
PDB IDs		6C0B 7N95 7N97 7N9S 7X8P
Enriched GO Terms of Interacting Partners?		Cerebellar Mossy Fiber Synaptic Vesicle Maturation P2Y1 Nucleotide Receptor Binding Axon Neuron Spine Positive Regulation Of Neuron Projection Arborization AMPA Glutamate Receptor Clustering Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Regulation Of Grooming Behavior NMDA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Juxtaparanode Region Of Axon Neuron Projection Terminus Locomotory Exploration Behavior Cellular Response To Potassium Ion Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Dendritic Spine Morphogenesis Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Negative Regulation Of Receptor Internalization Mitogen-activated Protein Kinase Kinase Kinase Binding Response To Potassium Ion Vocalization Behavior Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Cortical Cytoskeleton Ionotropic Glutamate Receptor Binding AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Dendritic Spine Organization Dendrite Cytoplasm Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Excitatory Synapse Wnt-protein Binding Protein Localization To Postsynapse Exploration Behavior Organelle Ligand-gated Ion Channel Signaling Pathway Neuron Projection Organization Postsynapse Organization Receptor Clustering Glutamate Receptor Signaling Pathway Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse
Tagcloud ?