ZBTB38

Description		zinc finger and BTB domain containing 38
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Blood Microparticle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Regulation Of DNA Replication Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Diastolic blood pressure ( 27618447) Estimated glomerular filtration rate ( 31152163) Fasting glucose ( 34059833) Hair color ( 29662168) Heel bone mineral density ( 30598549) Height ( 31562340 33713608 18193045 28270201 34270706 28552196 18391950 18391951 25282103 23563607 25429064 18391952 21998595 20881960 19343178 20189936 19893584 19396169) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Infant length ( 25281659) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602 31604244) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Physiological traits ( 31902109) Prion diseases ( 22210626) Prostate cancer ( 21743467) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Pulmonary function in asthmatics ( 25221879) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Serum total protein levels ( 29403010) Soluble receptor for advanced glycation end-product levels ( 26915486) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618447) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 28552196 25673412 34021172) Weight ( 28552196)
Novel Interacting Genes		19 novel interacting genes: CBFA2T3 CCDC136 EHMT2 ERCC6 FSD2 KCNJ6 KRT40 KRTAP10-7 KRTAP10-9 LZTS2 MTUS2 MYBPH PDE4DIP RALBP1 RBBP6 RSPH1 TRAPPC2 TRIM41 TSGA10
Interacting Genes		19 interacting genes: CBFA2T3 CCDC136 EHMT2 ERCC6 FSD2 KCNJ6 KRT40 KRTAP10-7 KRTAP10-9 LZTS2 MTUS2 MYBPH PDE4DIP RALBP1 RBBP6 RSPH1 TRAPPC2 TRIM41 TSGA10
Entrez ID		253461
HPRD ID		10985
Ensembl ID		ENSG00000177311
Uniprot IDs		Q8NAP3 Q9H6F0
PDB IDs		6E93 6E94
Enriched GO Terms of Interacting Partners?		Cytoskeleton Keratin Filament
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