NEIL2

Description		nei like DNA glycosylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Mitotic Spindle
	Molecular Function	Nucleic Acid Binding DNA Binding Damaged DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	DNA Repair Base-excision Repair DNA Damage Response Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		A body shape index ( 34021172) Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Systolic blood pressure ( 32902719) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		10 novel interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Interacting Genes		10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Entrez ID		252969
HPRD ID		16406
Ensembl ID		ENSG00000154328
Uniprot IDs		Q969S2
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Nuclear Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Peptidyl-lysine Propionylation Swimming Canonical NF-kappaB Signal Transduction Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Type I Interferon Production Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Beta-catenin Binding
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