FUT4

Description		fucosyltransferase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cell Surface Membrane Golgi Cisterna Membrane Cell Periphery
	Molecular Function	Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Protein O-linked Glycosylation Sphingolipid Metabolic Process Glycosphingolipid Biosynthetic Process Inflammatory Response Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Fucosylation L-fucose Catabolic Process Lymphocyte Migration Into Lymph Node Lewis X Epitope Biosynthetic Process Positive Regulation Of Neutrophil Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Lewis blood group biosynthesis
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Small cell lung carcinoma ( 28604730)
Novel Interacting Genes		3 novel interacting genes: CR1 ITGB2 SELP
Interacting Genes		3 interacting genes: CR1 ITGB2 SELP
Entrez ID		2526
HPRD ID		00083
Ensembl ID		ENSG00000196371
Uniprot IDs		P22083
PDB IDs
Enriched GO Terms of Interacting Partners?		Complement Component C3b Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane Raft Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Ficolin-1-rich Granule Membrane Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Immune System Process Integrin Binding Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Complement Component C4b Binding Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Activation Of Membrane Attack Complex Defense Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Complement Activation, Alternative Pathway Immune Complex Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules ICAM-3 Receptor Activity Leukocyte Migration Positive Regulation Of Neutrophil Degranulation Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Complement Activation ATP Export Platelet Dense Granule Membrane Glycosphingolipid Binding Negative Regulation Of B Cell Differentiation Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Neutrophil Degranulation External Side Of Plasma Membrane Fucose Binding
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