PSD4

Description		pleckstrin and Sec7 domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cleavage Furrow Ruffle Membrane Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding Lipid Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Red blood cell count ( 27863252 32888494) White blood cell count ( 32888494)
Novel Interacting Genes		2 novel interacting genes: LDLRAP1 USP9X
Interacting Genes		2 interacting genes: LDLRAP1 USP9X
Entrez ID		23550
HPRD ID		15191
Ensembl ID		ENSG00000125637
Uniprot IDs		Q8NDX1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding K11-linked Deubiquitinase Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Positive Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Positive Regulation Of TORC2 Signaling Regulation Of Intracellular Cholesterol Transport AP-2 Adaptor Complex Binding Regulation Of Intracellular Lipid Transport DNA Alkylation Repair Neurofilament Co-SMAD Binding Regulation Of TORC2 Signaling Protein Import Into Peroxisome Matrix Low-density Lipoprotein Particle Clearance Molecular Sequestering Activity Establishment Of Protein Localization To Peroxisome K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Peroxisomal Membrane Transport Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Peroxisome Organization Low-density Lipoprotein Particle Receptor Binding Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Clearance Amyloid Fibril Formation Positive Regulation Of Cholesterol Metabolic Process Intracellular Protein Transmembrane Transport Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Intracellular Transport Axon Extension Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Binding Receptor Metabolic Process Phosphotyrosine Residue Binding
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