NNT

Description		nicotinamide nucleotide transhydrogenase
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex
	Molecular Function	Nucleotide Binding NAD(P)+ Transhydrogenase (Si-specific) Activity Proton-translocating NAD(P)+ Transhydrogenase Activity Oxidoreductase Activity NADP Binding NAD Binding
	Biological Process	Tricarboxylic Acid Cycle NADPH Regeneration Positive Regulation Of Mitochondrial Membrane Potential Intracellular Oxygen Homeostasis Response To Vitamin Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Proton Transmembrane Transport Positive Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Citric acid cycle (TCA cycle)
Drugs		NADH 7-thionicotinamide-adenine-dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate Xanthinol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 30224653) Subcutaneous adipose tissue ( 29178545)
Novel Interacting Genes		1 novel interacting genes: MVP
Interacting Genes		1 interacting genes: MVP
Entrez ID		23530
HPRD ID		09715
Ensembl ID		ENSG00000112992
Uniprot IDs		E9PCX7 Q13423
PDB IDs		1DJL 1PT9 1U31
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Activation Cascade Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Phosphatase Binding Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Regulation Of ERBB Signaling Pathway Nuclear Pore Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation MRNA Transport Ficolin-1-rich Granule Lumen Secretory Granule Lumen Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process RNA Transport Nucleobase-containing Compound Transport Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Protein Maturation
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