KAT6B

Description		lysine acetyltransferase 6B
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GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-containing Complex Binding Metal Ion Binding Protein-lysine-acetyltransferase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Regulation Of Hemopoiesis
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847)
Novel Interacting Genes		6 novel interacting genes: ATN1 H3C1 RUNX1 RUNX2 UBE2I ZNF503
Interacting Genes		6 interacting genes: ATN1 H3C1 RUNX1 RUNX2 UBE2I ZNF503
Entrez ID		23522
HPRD ID		07065
Ensembl ID		ENSG00000156650
Uniprot IDs		B2RWN8 Q8WYB5
PDB IDs		5U2J 6OIE 8E4V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chondrocyte Differentiation Negative Regulation Of Biosynthetic Process Ligamentous Ossification Stem Cell Proliferation SUMO Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Ossification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Osteoblast Fate Commitment Regulation Of RNA Biosynthetic Process Core-binding Factor Complex RING-like Zinc Finger Domain Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Hemopoiesis Regulation Of Metabolic Process Cell Population Proliferation Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding G1 To G0 Transition Involved In Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Nucleus Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Nucleoplasm Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Sodium Phosphate Negative Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Negative Regulation Of Granulocyte Differentiation Mitotic Nuclear Membrane Reassembly Peripheral Nervous System Neuron Development Gene Expression Transferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Connective Tissue Replacement
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