SPIDR

Description		scaffold protein involved in DNA repair
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm
	Molecular Function	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Establishment Of Protein Localization To Chromosome Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin Positive Regulation Of Double-strand Break Repair
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)
Novel Interacting Genes		3 novel interacting genes: BLM EIF2AK2 FIGNL1
Interacting Genes		3 interacting genes: BLM EIF2AK2 FIGNL1
Entrez ID		23514
HPRD ID		19305
Ensembl ID		ENSG00000164808
Uniprot IDs		B3KP42 B4DWT8 Q14159
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Chromosome Cellular Response To Ionizing Radiation Regulation Of DNA Recombination ATP Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Forked DNA-dependent Helicase Activity Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Cellular Response To Radiation RecQ Family Helicase-topoisomerase III Complex Response To Ionizing Radiation Telomeric D-loop Binding Y-form DNA Binding Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Nucleotide Binding Four-way Junction Helicase Activity Cellular Response To Camptothecin Microtubule Severing ATPase Activity DNA Geometric Change Resolution Of DNA Recombination Intermediates ATP Hydrolysis Activity Telomeric D-loop Disassembly Bubble DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Microtubule Severing T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Response To Radiation Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Osteoblast Proliferation 3'-5' DNA Helicase Activity Negative Regulation Of Osteoblast Proliferation Regulation Of DNA Metabolic Process Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding Regulation Of Cellular Response To Stress Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation DNA Conformation Change Positive Regulation Of Stress-activated MAPK Cascade Response To Interferon-alpha DNA Double-strand Break Processing Response To X-ray Perinuclear Region Of Cytoplasm Replication Fork Regulation Of Osteoblast Proliferation
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