ISCU

Description		iron-sulfur cluster assembly enzyme
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Molecular Adaptor Activity Iron-sulfur Cluster Chaperone Activity
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Iron Ion Import Across Plasma Membrane
Pathways		Maturation of replicase proteins
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Intraocular pressure ( 29617998)
Novel Interacting Genes		18 novel interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 JUN KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1
Interacting Genes		18 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 JUN KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1
Entrez ID		23479
HPRD ID		14828
Ensembl ID		ENSG00000136003
Uniprot IDs		B1P7G3 B3KQ30 B4DNC9 Q9H1K1
PDB IDs		5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH 7RTK 8PK8 8PK9 8PKA 8RMC 8RMD 8RME 8RMF 8RMG 8TVT
Enriched GO Terms of Interacting Partners?		Identical Protein Binding
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