SMG5

Description		SMG5 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 29403010)
Novel Interacting Genes		10 novel interacting genes: APP BTG3 CKB PLEKHO1 SMG1 SMG6 SMG7 STUB1 TERT UPF1
Interacting Genes		10 interacting genes: APP BTG3 CKB PLEKHO1 SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		23381
HPRD ID		16869
Ensembl ID		ENSG00000198952
Uniprot IDs		Q9UPR3
PDB IDs		2HWY
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Telomerase RNA Binding Telomerase Holoenzyme Complex Nuclear-transcribed MRNA Catabolic Process Nuclear Export MRNA Transport MRNA Catabolic Process RNA Transport RNA Catabolic Process Nucleobase-containing Compound Transport Intracellular Transport Protein-folding Chaperone Binding Regulation Of Telomere Maintenance Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Cellular Localization Establishment Of Localization In Cell Regulation Of Dephosphorylation Chromosome, Telomeric Region Cytoplasm Macromolecule Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress MRNA Metabolic Process Regulation Of Chromosome Organization Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Metabolic Process TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Metabolic Process G Protein-coupled Receptor Binding Regulation Of MiRNA Transcription Nucleus Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Response To Interleukin-1
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