SYNM

Description		synemin
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Adherens Junction Membrane Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton Anchoring Junction
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding
	Biological Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)
Novel Interacting Genes		8 novel interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PCSK6 PKNOX1 SELENOS
Interacting Genes		8 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PCSK6 PKNOX1 SELENOS
Entrez ID		23336
HPRD ID		07305
Ensembl ID		ENSG00000182253
Uniprot IDs		A0A075B7B1 O15061
PDB IDs		6EWO
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Junction ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Basolateral Plasma Membrane Animal Organ Development Growth Factor Binding Intermediate Filament Cytoskeleton Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Protein Localization To Synapse Embryonic Pattern Specification Glial Cell Development Negative Regulation Of Apoptotic Process Protein-containing Complex Localization Negative Regulation Of Programmed Cell Death Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neuron Differentiation Plasma Membrane Regulation Of Epithelial Cell Proliferation Wound Healing Protein Localization To Cell Junction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development Central Nervous System Morphogenesis Nerve Growth Factor Production
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