CUX2

Description		cut like homeobox 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Short-term Memory Positive Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of Dendrite Morphogenesis Cognition Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 29403010) Alanine aminotransferase levels ( 33339817) Alanine transaminase levels ( 29403010) Alcohol consumption (max-drinks) ( 29460428) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Atrial fibrillation ( 28416822) Blood osmolality (transformed sodium) ( 28360221) Blood sugar levels ( 29403010) Blood urea nitrogen levels ( 29403010) Body mass index ( 26426971) Chloride levels ( 29403010) Coffee consumption ( 29367735 31345160) Colorectal cancer ( 26151821) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Coronary artery disease ( 32469254) Coronary heart disease ( 23364394) Creatinine levels ( 29403010) Diastolic blood pressure ( 29403010 30487518) Epilepsy ( 33913524) Estimated glomerular filtration rate ( 31152163 30604766) Gamma glutamyl transferase levels ( 29403010 33339817) Glomerular filtration rate ( 29403010) Gout ( 27899376 25646370) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Hypertension ( 30487518) Idiopathic osteonecrosis of the femoral head ( 29118346) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 29403010) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 30487518 29403010) Red blood cell count ( 29403010) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376) Response to alcohol consumption (flushing response) ( 29460428) Serum uric acid levels ( 30993211 32514006 29403010) Smoking behaviour (cigarettes smoked per day) ( 31089300) Sodium levels ( 29403010) Systolic blood pressure ( 29403010) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 1 diabetes ( 22293688) Urate levels ( 31578528) Waist-hip ratio ( 34054925) Weight ( 34054925)
Novel Interacting Genes		1 novel interacting genes: CSNK2A1
Interacting Genes		1 interacting genes: CSNK2A1
Entrez ID		23316
HPRD ID		10851
Ensembl ID		ENSG00000111249
Uniprot IDs		O14529
PDB IDs		1WH6 1WH8 1X2L
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Sin3-type Complex PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Execution Phase Of Apoptosis RNA Decapping Protein Localization To Site Of Double-strand Break Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Negative Regulation Of Signal Transduction By P53 Class Mediator Hsp90 Protein Binding Negative Regulation Of Double-strand Break Repair Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Chromosome Separation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Translational Initiation Protein Localization To Vacuole Positive Regulation Of Macroautophagy Protein Localization To Chromosome Nuclear-transcribed MRNA Catabolic Process DNA Damage Checkpoint Signaling PML Body Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Recombinational Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Proteolysis Double-strand Break Repair Via Homologous Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway MRNA Catabolic Process Regulation Of Double-strand Break Repair Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Growth
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