FBXW11

Description		F-box and WD repeat domain containing 11
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule SCF Ubiquitin Ligase Complex Neuron Projection Neuronal Cell Body Axon Cytoplasm
	Molecular Function	Protein Binding Protein Dimerization Activity Microtubule Plus-end Binding Dynein Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Protein Polyubiquitination Protein Dephosphorylation Nuclear Migration Germ Cell Development Retrograde Axonal Transport Wnt Signaling Pathway Protein Ubiquitination Microtubule Organizing Center Organization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Positive Regulation Of Circadian Rhythm Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Vesicle Transport Along Microtubule Rhythmic Process Brain Morphogenesis
Pathways		Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins
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Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 20881960 23563607 25282103 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172)
Novel Interacting Genes		29 novel interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 MITF NFE2L2 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN RIPK4 TBC1D4 TFE3 TRIM21 UBE2D3 WEE1 ZNF281
Interacting Genes		29 interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 MITF NFE2L2 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN RIPK4 TBC1D4 TFE3 TRIM21 UBE2D3 WEE1 ZNF281
Entrez ID		23291
HPRD ID		07294
Ensembl ID		ENSG00000072803
Uniprot IDs		B4DH70 E5RGC1 Q9UKB1
PDB IDs		6WNX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Response To Peptide Negative Regulation Of Metabolic Process Response To Cytokine Regulation Of Autophagy Positive Regulation Of Autophagy Nucleus Signal Transduction Intracellular Signaling Cassette Protein Modification Process Nucleoplasm Intracellular Signal Transduction Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Rhythmic Process Cellular Response To Cytokine Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Proteasomal Protein Catabolic Process TOR Signaling Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macrophage Derived Foam Cell Differentiation Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Proteolysis
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