KLHL18

Description		kelch like family member 18
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: AURKA CFTR EEF1G SCAP SETD2
Interacting Genes		5 interacting genes: AURKA CFTR EEF1G SCAP SETD2
Entrez ID		23276
HPRD ID		10017
Ensembl ID		ENSG00000114648
Uniprot IDs		O94889
PDB IDs
Enriched GO Terms of Interacting Partners?		Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Cytokinesis Microtubule Cytoskeleton Organization Involved In Mitosis Response To Vitamin B3 SREBP-SCAP Complex Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Regulation Of Cell Division Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Alcohol Metabolic Process Chloride Channel Inhibitor Activity Transepithelial Water Transport Steroid Metabolic Process Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Basolateral Plasma Membrane Pronucleus Chromosome Passenger Complex Positive Regulation Of Cell Maturation Mitotic Centrosome Separation Axon Hillock Sterol Binding Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Histone H3K36 Trimethyltransferase Activity Regulation Of Protein Localization To Chromatin Peptidyl-lysine Trimethylation ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of MRNA Export From Nucleus Histone H3K36 Methyltransferase Activity Cilium Disassembly Response To Sterol Depletion Centrosome Separation Spindle Assembly Involved In Female Meiosis Response To Type I Interferon
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