COBL

Description		cordon-bleu WH2 repeat protein
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Cell Projection Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Terminal Web
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding
	Biological Process	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Cytoskeleton Organization Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 33074286) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Fractures ( 30158200) Late-onset Alzheimer's disease ( 27770636) Macular thickness ( 30535121) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Type 1 diabetes ( 19430480) Urate levels in obese individuals ( 25811787) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920) Wegener's granulomatosis ( 23740775)
Novel Interacting Genes		2 novel interacting genes: ALAS1 NLGN3
Interacting Genes		2 interacting genes: ALAS1 NLGN3
Entrez ID		23242
HPRD ID		10843
Ensembl ID		ENSG00000106078
Uniprot IDs		O75128
PDB IDs		4PL8
Enriched GO Terms of Interacting Partners?		Heme O Biosynthetic Process Response To Herbicide Response To Cobalt Ion 5-aminolevulinate Synthase Activity Response To Nickel Cation Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Hemoglobin Biosynthetic Process Heme B Biosynthetic Process Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynaptic Membrane Organization Hemoglobin Metabolic Process Protoporphyrinogen IX Metabolic Process Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Presynapse Organization Vocalization Behavior Heme Biosynthetic Process Regulation Of Respiratory Gaseous Exchange Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Response To Gonadotropin Erythrocyte Development Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Synapse Heme Metabolic Process Synaptic Vesicle Endocytosis Porphyrin-containing Compound Metabolic Process Presynaptic Endocytosis Axon Extension Modulation Of Excitatory Postsynaptic Potential Pyridoxal Phosphate Binding Tetrapyrrole Metabolic Process Pigment Metabolic Process Social Behavior
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