PLCB1

Description		phospholipase C beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Membrane Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Identical Protein Binding Phosphatidylinositol Phospholipase C Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Learning Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Lipid Catabolic Process Cerebral Cortex Development Phosphatidylinositol Catabolic Process Positive Regulation Of Insulin Secretion Positive Regulation Of Interleukin-12 Production Inositol Trisphosphate Metabolic Process Response To Monosaccharide Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Response To Peptide Hormone Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Release Of Sequestered Calcium Ion Into Cytosol Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Fluoride Regulation Of Establishment Of Endothelial Barrier Cellular Response To Vasopressin Cellular Response To Ionomycin Cellular Response To Glyceraldehyde Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34074324) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neuritic plaque ( 31497858) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Response to irinotecan in non-small-cell lung cancer ( 22664479) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 32888494 27863252)
Novel Interacting Genes		18 novel interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 NHERF1 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SPTBN1 TFCP2 TRPC3 TRPM7
Interacting Genes		18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 NHERF1 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SPTBN1 TFCP2 TRPC3 TRPM7
Entrez ID		23236
HPRD ID		06177
Ensembl ID		ENSG00000182621
Uniprot IDs		Q9NQ66
PDB IDs
Enriched GO Terms of Interacting Partners?		Viral Genome Replication Protein Phosphorylation Protein Serine/threonine Kinase Activity Phosphorylation Interleukin-34-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Protein Kinase Activity Plasma Membrane Protein Kinase C Signaling Regulation Of Cellular Localization Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of System Process Viral Process PAR Polarity Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cardiac Neural Crest Cell Development Involved In Heart Development Phosphatase Binding Trachea Formation Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Platelet Activation Protein Serine Kinase Activity Kinase Activity Regulation Of Multicellular Organismal Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Bergmann Glial Cell Differentiation Regulation Of Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Regulation Of Biological Quality Regulation Of Muscle System Process White Fat Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Golgi Organization MAP Kinase Activity Myelination Axon Ensheathment Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cytoskeleton Organization Schwann Cell Development Intracellular Chemical Homeostasis Ruffle
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