RRS1

Description		regulator of ribosome synthesis 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Preribosome, Large Subunit Precursor
	Molecular Function	RNA Binding Protein Binding 5S RRNA Binding
	Biological Process	Ribosomal Large Subunit Assembly Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hematopoietic Progenitor Cell Differentiation Mitotic Metaphase Chromosome Alignment Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Novel Interacting Genes		5 novel interacting genes: APPBP2 CFTR FXYD2 OGT SDCBP
Interacting Genes		5 interacting genes: APPBP2 CFTR FXYD2 OGT SDCBP
Entrez ID		23212
HPRD ID		15277
Ensembl ID		ENSG00000179041
Uniprot IDs		Q15050
PDB IDs		8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FL0 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Intracellular Chemical Homeostasis Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Homeostasis Positive Regulation Of Transport Chemical Homeostasis Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Exocytosis Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Protein O-acetylglucosaminyltransferase Activity Hyperosmotic Salinity Response Ion Channel Regulator Activity Cellular Hyperosmotic Salinity Response Basolateral Plasma Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Extracellular Exosome Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Sodium Ion Export Across Plasma Membrane Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Salt Stress Amelogenesis Positive Regulation Of Secretion By Cell ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Substrate-dependent Cell Migration, Cell Extension Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By Glucose Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
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