FBXL7

Description		F-box and leucine rich repeat protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Haemorrhoidal disease ( 33888516) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)
Novel Interacting Genes		6 novel interacting genes: APP FBXL18 FCHO1 IMPDH2 PFKFB4 TBC1D5
Interacting Genes		6 interacting genes: APP FBXL18 FCHO1 IMPDH2 PFKFB4 TBC1D5
Entrez ID		23194
HPRD ID		05740
Ensembl ID		ENSG00000183580
Uniprot IDs		Q9UJT9
PDB IDs
Enriched GO Terms of Interacting Partners?		AP-2 Adaptor Complex Binding Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Cytosol Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling IMP Dehydrogenase Activity Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity 'de Novo' XMP Biosynthetic Process Atg1/ULK1 Kinase Complex Peptidase Activator Activity
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