RTF1

Description		RTF1 homolog, Paf1/RNA polymerase II complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Blastocyst Growth Chromatin Organization Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Asthma ( 32296059) Coronary artery disease ( 29212778) Eosinophil percentage of granulocytes ( 27863252) Height ( 20881960) Itch intensity from mosquito bite ( 28199695) Ulcerative colitis ( 28067908)
Novel Interacting Genes		5 novel interacting genes: APP SRPK2 TCEA1 UBC VPS39
Interacting Genes		5 interacting genes: APP SRPK2 TCEA1 UBC VPS39
Entrez ID		23168
HPRD ID		11071
Ensembl ID		ENSG00000137815
Uniprot IDs		Q92541
PDB IDs		2BZE 2DB9 3U1U 4L1P 4L1U 6TED 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lysosomal HOPS Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nuclear Speck Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Presynapse Axon Choice Point Recognition Regulation Of Neuron Apoptotic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion R-loop Processing Endosome Membrane Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding
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