SPART

Description		spartin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Protein Binding Lipid Binding Ubiquitin Protein Ligase Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipid Catabolic Process BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Collateral Sprouting In Absence Of Injury Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Lipophagy Midbody Abscission Regulation Of Biological Quality
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS
Novel Interacting Genes		22 novel interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 POSTN PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Interacting Genes		22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 POSTN PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		23111
HPRD ID		06170
Ensembl ID		ENSG00000133104
Uniprot IDs		A0A024RDV9 Q8N0X7
PDB IDs		2DL1 4U7I
Enriched GO Terms of Interacting Partners?		Cysteine-type Deubiquitinase Activity Protein K48-linked Deubiquitination Early Endosome Membrane Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Cytosol K48-linked Deubiquitinase Activity Endosome Early Endosome Deubiquitinase Activity Protein K63-linked Deubiquitination Proteolysis Protein Modification Process Cytoplasm Endocytosis Peptidase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization Import Into Cell Protein Ubiquitination Response To Mechanical Stimulus Negative Regulation Of Leukocyte Activation Regulation Of Immune Response Neuromuscular Junction Negative Regulation Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cell Activation Protein Modification By Small Protein Conjugation K63-linked Deubiquitinase Activity Regulation Of Notch Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ubiquitin Binding Regulation Of Signaling Ubiquitin Ligase Complex Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Vesicle-mediated Transport Symbiont Entry Into Host Cell Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Transporter Activity Regulation Of Signal Transduction
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