IQSEC2

Description		IQ motif and Sec7 domain ArfGEF 2
Image
GO Annotations	Cellular Component	Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Long-term Synaptic Depression
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Neutrophil count ( 32888494)
Novel Interacting Genes		6 novel interacting genes: CALM1 CALM2 CALM3 FOXP1 PRMT2 SNCA
Interacting Genes		6 interacting genes: CALM1 CALM2 CALM3 FOXP1 PRMT2 SNCA
Entrez ID		23096
HPRD ID		10012
Ensembl ID		ENSG00000124313
Uniprot IDs		A0A1W2PR28 Q5JU85
PDB IDs		6FAE
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Long-term Synaptic Potentiation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Titin Binding Detection Of Calcium Ion Vesicle-mediated Transport In Synapse Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Vesicle Membrane Negative Regulation Of Transporter Activity Calcium Channel Complex Presynaptic Cytosol Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Calcineurin-mediated Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Regulation Of Synaptic Plasticity Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of Calcium Ion Transport Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Muscle System Process Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Monoatomic Cation Transmembrane Transport Neural Nucleus Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex
Tagcloud ?