SETD1B

Description		SET domain containing 1B, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Methylation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 24026423 32888494) Mean spheric corpuscular volume ( 32888494)
Novel Interacting Genes		5 novel interacting genes: H3C1 H3C14 H3C6 RNF10 WDR82
Interacting Genes		5 interacting genes: H3C1 H3C14 H3C6 RNF10 WDR82
Entrez ID		23067
HPRD ID		19516
Ensembl ID		ENSG00000139718
Uniprot IDs		Q9UPS6
PDB IDs		3UVO 4ES0 8ILZ 8WXV
Enriched GO Terms of Interacting Partners?		Gene Expression Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Chromosome Protein-DNA Complex Assembly Protein Heterodimerization Activity Macromolecule Biosynthetic Process Chromatin Remodeling Telomere Organization LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription DNA Binding Chromatin Organization Regulation Of Gene Expression Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process PTW/PP1 Phosphatase Complex Negative Regulation Of Schwann Cell Proliferation RNA Polymerase II Promoter Clearance Epigenetic Regulation Of Gene Expression Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Cadherin Binding Protein-containing Complex Assembly Chromosome Organization Set1C/COMPASS Complex Regulation Of Metabolic Process Protein-containing Complex Organization Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Myelination DNA-templated Transcription Termination Nucleus Chromatin Binding Negative Regulation Of DNA-templated Transcription, Elongation Histone Methyltransferase Complex LncRNA Binding Nuclear RNA Surveillance Nucleoplasm RNA Surveillance Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Extracellular Exosome Postsynaptic Signal Transduction Extracellular Region Protein Monoubiquitination
Tagcloud ?