TNIK

Description		TRAF2 and NCK interacting kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)
Novel Interacting Genes		39 novel interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Interacting Genes		39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		23043
HPRD ID		18206
Ensembl ID		ENSG00000154310
Uniprot IDs		Q9UKE5
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity
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