PDZRN3

Description		PDZ domain containing ring finger 3
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GO Annotations	Cellular Component	Cytoplasm Neuromuscular Junction Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Neuromuscular Junction Development Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Mercury levels ( 26025379) Mitochondrial DNA copy number (white blood cells) ( 30704525) PR interval ( 30046033 30679814 32439900)
Novel Interacting Genes		8 novel interacting genes: BMPR2 EFNB2 LNX1 LNX2 RPS6KA1 SLC5A8 UBE2D2 VANGL2
Interacting Genes		8 interacting genes: BMPR2 EFNB2 LNX1 LNX2 RPS6KA1 SLC5A8 UBE2D2 VANGL2
Entrez ID		23024
HPRD ID		15115
Ensembl ID		ENSG00000121440
Uniprot IDs		B7Z2I8 B7Z5Q3 B7Z5X9 B7ZAG0 E7ENB6 Q9UPQ7
PDB IDs		1UHP 1WH1
Enriched GO Terms of Interacting Partners?		Epithelial Cell Proliferation Tube Morphogenesis Blood Vessel Morphogenesis Apical Plasma Membrane Animal Organ Morphogenesis Proteoglycan Metabolic Process System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Activin Receptor Activity, Type II Cell Population Proliferation Proteoglycan Biosynthetic Process Epithelial Tube Morphogenesis Postsynaptic Density Membrane Positive Regulation Of Aorta Morphogenesis Ubiquitin-protein Transferase Activity Serotonergic Neuron Axon Guidance Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis PDZ Domain Binding Acetate Transport Monocarboxylate:sodium Symporter Activity Short-chain Fatty Acid Transmembrane Transport Organic Acid:sodium Symporter Activity Nitrate Transmembrane Transport Propanoate Transmembrane Transport Short-chain Fatty Acid Transport Propionate Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Nicotinate Transport Iodide Channel Activity Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Aorta Morphogenesis Nervous System Development Apical Cytoplasm Establishment Of Body Hair Planar Orientation Anterior/posterior Pattern Specification Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation
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