SPEN

Description		spen family transcriptional repressor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Neurogenesis Random Inactivation Of X Chromosome
Pathways		RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)
Novel Interacting Genes		24 novel interacting genes: ATXN1 CLK1 CRK CTBP1 DLX5 HDAC1 HDAC2 ITCH MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Interacting Genes		24 interacting genes: ATXN1 CLK1 CRK CTBP1 DLX5 HDAC1 HDAC2 ITCH MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		23013
HPRD ID		10230
Ensembl ID		ENSG00000065526
Uniprot IDs		Q96T58
PDB IDs		1OW1 2RT5 4P6Q 7Z1K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Stem Cell Differentiation NuRD Complex Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Cell Population Proliferation Histone Deacetylase Binding Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein-containing Complex Regulation Of Cell Differentiation Nucleosomal DNA Binding Histone Deacetylase Complex DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Transcription Cis-regulatory Region Binding Regulation Of Developmental Process Regulation Of MiRNA Transcription Nucleoplasm DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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