ALDOB

Description		aldolase, fructose-bisphosphate B
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GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Centriolar Satellite Extracellular Exosome
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity Identical Protein Binding ATPase Binding Molecular Adaptor Activity Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Fructose Metabolic Process Fructose Catabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Pentose-phosphate Shunt
Pathways		Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs		1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		Hereditary fructose intolerance; Fructosemia
GWAS		Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33339817 33547301)
Novel Interacting Genes		22 novel interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40
Interacting Genes		22 interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40
Entrez ID		229
HPRD ID		01972
Ensembl ID		ENSG00000136872
Uniprot IDs		P05062
PDB IDs		1QO5 1XDL 1XDM 8D44
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Chiasma Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Import Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Homeostatic Process Mismatch Repair Complex Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Mesendoderm Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Glycolytic Process Signaling Receptor Activator Activity Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Negative Regulation Of Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Epithelial Cell Proliferation Cellular Response To Stress Apoptotic Process Regulation Of Growth Regulation Of Carbohydrate Catabolic Process Cytosol Mismatched DNA Binding Regulation Of Protein Stability Regulation Of Protein Localization Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Regulation Of ATP Metabolic Process Enzyme Binding Regulation Of MiRNA Transcription Negative Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Reproductive Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Cell Differentiation
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