CHSY1

Description		chondroitin sulfate synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity
	Biological Process	Chondrocyte Development Proximal/distal Pattern Formation Negative Regulation Of Ossification Response To Nutrient Levels Positive Regulation Of Smoothened Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Cartilage Development Sulfation Bone Morphogenesis
Pathways		CS-GAG biosynthesis Defective CHSY1 causes TPBS
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Appendicular lean mass ( 33097823) Basophil count ( 32888494) Central corneal thickness ( 31798171 29760442) Corneal structure ( 23291589) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Relative hand skill in reading disability ( 24068947) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: FOXP1
Interacting Genes		1 interacting genes: FOXP1
Entrez ID		22856
HPRD ID		10493
Ensembl ID		ENSG00000131873
Uniprot IDs		Q86X52
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-21 Production Monocyte Activation Regulation Of Defense Response To Bacterium Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Osteoclast Development Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Positive Regulation Of B Cell Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation Core Promoter Sequence-specific DNA Binding Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Nuclear Androgen Receptor Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation T-helper Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Muscle Hypertrophy Response To Testosterone Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Organ Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy T Cell Differentiation Involved In Immune Response Osteoclast Differentiation CD4-positive, Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Regulation Of Heart Growth Macrophage Activation Alpha-beta T Cell Differentiation Forebrain Development Regulation Of Lymphocyte Apoptotic Process CD4-positive, Alpha-beta T Cell Activation Regulation Of Morphogenesis Of An Epithelium Myeloid Cell Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Interleukin-12 Production Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation
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